The ION* product suite is built upon the fundamental belief of allowing nature's intelligence to guide us. Equally significant is our unwavering commitment to the scientific process. By keenly observing, we gain valuable insights into the complexities of nature. Our understanding is derived from thorough testing and the evidence we gather from the natural world, enabling us to comprehend the interconnectedness of all things. While nature possesses the solutions, it is our responsibility to illuminate her wisdom.
ION* focus lies in connection, starting from the very core of our scientific research: the preservation of tight junction integrity. Tight junctions serve as protective seals between your cells, forming defensive barriers in the gut, skin, and sinuses. They play a crucial role in preventing toxins and foreign particles from entering the bloodstream, while allowing essential nutrients to pass through. These seals are safeguarded by the carbon and mineral metabolites produced during bacterial digestion.
The foundation of ION* is rooted in the ongoing and essential communication that takes place between human cells and the microbiome within the body. By stimulating this communication within the gut microbiome, ION* plays a crucial role in enhancing the cellular integrity of the gut’s protective barriers. Maintaining the connection between cells ensures the preservation of these barriers, creating an optimal environment for seamless interaction between individuals and their microbiome.
Regrettably, tight junction barriers can be compromised by factors such as gluten, glyphosate (the primary chemical found in commercial herbicides like Roundup), and other environmental stressors. However, ION* has been scientifically proven to enhance the fortification of these barriers through redox signaling, even in the presence of such environmental challenges.
Redox signalling is perhaps the most complex aspect of our science. And yet, at its core, it’s simply how your cells communicate.
Redox signalling is a fundamental network, a fluency of electrons, moving in lightning-fast patterns through the cell. Mitochondria (organelles within the cell) generate redox signals as they create electrical power to fuel biology. Cells monitor these signals as sets of instructions.
Reactive oxygen species (or ROS) are also a fundamental part of the process. Natural by-products of cellular metabolism, ROS function in two ways – by promoting the signalling that maintains physiological functions and by causing oxidative stress.
A good balance is ultimately the goal. This is why ION* is unlike any other gut health product; it fosters natural communication inherent within your unique system, helping to promote balance.
Terrahydrite®, the innovative blend utilized across our entire ION* line, is a signal, not a nutrient. Without actively doing or adding anything to the body, the presence of ION* amplifies the body’s natural communication networks to selectively induce appropriate modulation of ROS depending on the condition of the cell. This means it helps to reduce ROS in healthy cells (which indicates greater efficiency in energy production), and increases ROS in cells which need immune intervention or repair.
We call this the intelligence of nature, because rather than forcing response at the cellular level, the signalling molecules in ION* amplify the cells’ own communication pathways, resulting in appropriate adaptation to the intracellular and extracellular environment.
But, how?
Well, the ancient soil from which ION* is derived contains the same redox signalling molecules that are naturally produced by your own bacteria. These bacterial metabolites reinforce the communication network that already exists within you.
By supporting a beneficial shift in bacterial composition, ION* supports the body’s natural drive to cultivate the types of microbes that reinforce your cellular integrity… and by reinforcing cellular integrity, the terrain upon which your gut microbiome resides can strengthen itself, further promoting its ability to diversify and thrive. Talk about symbiosis.
Your body’s defence understands it is to allow essential nutrients to pass through while blocking harmful toxins. However, these defences need to be robust. ION* has been proven to enhance the body’s internal communication pathways, supporting the integrity of tight junctions. By fortifying these tight junctions, your body’s natural barriers are reinforced at a cellular level, thus enhancing the effectiveness of your immune system at its core.
Your immune system’s function is to identify and eradicate pathogens, and that process begins at your body’s barriers to the outside world. Research indicates that 70% or more of the body’s pathogen-fighting white blood cells reside in the gut. By sparking the body’s natural ability to keep your barriers strong, pathogens are obstructed before your immune system is exposed to their damaging effects.
Just like you, your microbiome needs a healthy, hospitable environment to thrive. Think of your skin, gut lining, and nasal passages as terrains – upon which the health of your microbiome depends. This is where we come in. By supporting the terrain (cellular integrity), ION* facilitates the body to create microbiome health at its literal foundation.
Healthy membranes (skin, gut, sinuses) facilitate movement of minerals and nutrients across cell membranes, also pulling in water. By improving cellular integrity and reinforcing those membranes, the body can better regulate water absorption.
Stronger tight junctions = better nutrient absorption and hydration.
Collagen is most associated with improving elasticity, supporting hydration, and reducing signs of aging in the skin. However, the benefits of healthy collagen formation go far deeper, helping with everything from muscle strength to joint pain to heart health. ION* has been scientifically shown to support lysine production – one of the fundamental precursors of collagen formation.
Explores the connection between the microbiome and the gut and blood-brain barrier systems, as well as the improved effect that ION* has on the blood-brain barrier.
Establishes the capacity of ION* to block glyphosate-mediated injury in small intestinal and colon epithelial membranes.
Reveals that the addition of ION* stabilizes tight junction integrity even in the face of gluten exposure.
In addition to peer-reviewed studies, ION* conducted two foundational double-blind, placebo-controlled clinical trials that demonstrate the ability of ION* Intelligence of Nature to promote innate health in two important ways: lysine production and immune function.
This clinical trial, which was double-blind and placebo-controlled, demonstrates the ability of ION* Gut + Microbiome to enhance the production of lysine by the microbiome. This amino acid plays a crucial role in protein synthesis, epigenetic regulation, collagen formation, immune system modulation, and various cellular processes.
Lysine is indispensable for human cells as it cannot be synthesized internally and must be acquired through dietary sources. It is generated by different bacteria, fungi, and plants via distinct enzyme pathways and acts as a fundamental component for numerous proteins in the human body. These proteins are essential for the synthesis of hormones, immune cells, and enzymes, highlighting the significance of lysine in various physiological functions.
This double-blind, placebo-controlled clinical trial validates the marked effect that ION* Gut Support has on reducing zonulin, IL-6 (an inflammatory marker), and glyphosate. Specifically, ION* Gut Support reduced zonulin by 12%, IL-6 by 17%, and glyphosate levels in the urine of adult humans by 23% over a two-week course without change in diet or exercise behavior.
Reduced zonulin could be in part due to the upregulation of the enzyme DPP4 by intestinal epithelial cells which would prevent the production of, and accelerate the removal of, zonulin in the pericellular space.
Reduced glyphosate levels are likely the result of multiple biologic pathways, including strengthened tight junction integrity, which would improve the regulatory capacity of the barrier system, keeping synthetic and naturally occurring toxins out of the immune and vascular systems.
Reduced IL-6, an inflammatory marker, could reflect a decreased antigen presentation to the innate immune system as a result of diminished levels of glyphosate and reduced intestinal permeability as reflected by the drop in urine zonulin in the same group of individuals.
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